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| Second Basemen Career Homeruns Leaderboard | |
| * - Indicates Hall of Fame Bold - Indicates active player |
| Rank | Player | Homeruns | PA | Years | Single Season Leaderboard |
| 1. | Tim Manning | 5 | 628 | 1884-1884 | |
| 2. | Buck Ewing | 4 | 639 | 1884-1884 | |
| Bid McPhee | 4 | 610 | 1884-1884 | ||
| 4. | Jack Farrell | 3 | 657 | 1884-1884 | |
| Fred Dunlap | 3 | 630 | 1884-1884 | ||
| Frank McLaughlin | 3 | 495 | 1884-1884 | ||
| 7. | Mike Moynahan | 2 | 469 | 1884-1884 | |
| Sam Barkley | 2 | 389 | 1884-1884 | ||
| 9. | Hugh Nicol | 1 | 331 | 1884-1884 | |
| Ed Caskin | 1 | 273 | 1884-1884 | ||
| Dickie Flowers | 1 | 121 | 1884-1884 | ||
| Harry Wheeler | 1 | 114 | 1884-1884 | ||
| Ross Barnes | 1 | 101 | 1884-1884 | ||
| Charlie Dougherty | 1 | 81 | 1884-1884 |
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